Early Detection of Cancer and Targeted Treatment Saves Lives
bioAffinity Technologies, Inc. (NASDAQ: BIAF) addresses the urgent need for noninvasive, early-stage cancer diagnosis and targeted cancer treatment. Our first product, CyPath® Lung, accurately diagnoses early-stage lung cancer, the leading cause of cancer-related deaths, with the potential to dramatically increase overall diagnostic accuracy of lung cancer leading to increased survival, fewer unnecessary invasive procedures, reduced patient anxiety, and lower medical costs. CyPath® Lung has shown high sensitivity and high specificity in detecting early-stage lung cancer and is marketed as a Laboratory Developed Test (LDT) by Precision Pathology Services in San Antonio, Texas.
Statement from Our CEO
“CyPath® Lung, our non-invasive test to detect lung cancer at its early stages when treatment is most effective, leading to significantly lowering the death rate of this deadliest of cancers.
The hard-working scientists and other professionals at bioAffinity are committed to bringing to market products that give people longer, healthier lives by the early detection of cancer and other lung diseases, and advancing therapeutic discoveries that treat cancer at the cellular level.
Flow cytometry allows for analysis of whole cells and cell populations that make up the lung environment. Our research provides a better understanding of how disease changes the lung environment and how flow cytometry can be used as a diagnostic tool by analyzing sputum for the presence of lung cancer, as well as other diseases such as COPD and asthma.”
— bioAffinity Technologies CEO, Maria Zannes
The Company’s Why
President & CEO Maria Zannes discusses the origins of the company and why we are strongly dedicated to the mission of early diagnosis and treatment in the fight against cancer.
President and Chief Executive Officer
Ms. Zannes brings more than 30 years of executive-level management experience dedicated to defining and advancing company goals and overcoming obstacles impeding corporate success. Prior to her position at bioAffinity Technologies, Ms. Zannes founded The Zannes Firm focusing on strategic solutions for private industry in the medical, environmental and energy fields. In her current capacity as bioAffinity Technologies CEO and President, she has built a team of award-winning scientists and executives who are advancing breakthrough oncology-focused diagnostics and therapeutics.
Ms. Zannes was President of the Energy Recovery Council, the national trade group for the $10 billion waste-to-energy industry, and General Manager of ECOS Corporation, a subsidiary of Burlington Environmental. Ms. Zannes also served as a project manager at Wheelabrator Technologies, Inc. where she led project teams that developed, negotiated and financed the company’s renewable energy generation facilities. Ms. Zannes began her career as a journalist, working for Voice of America and the Associated Press. Before entering the business world, she served as a legislative aide specializing in energy policy and law for Congressman Charles Wilson (D-TX). She is licensed to practice law in New Mexico. She has been awarded Lifetime Achievement Awards by the American Society of Mechanical Engineers and the Earth Engineering Center Award from the WTE Council of Columbia University.
She is the co-founder of two engineering research centers at Columbia University. Ms. Zannes received her B.A. in Journalism from the University of New Mexico and her J.D. from the University of Puget Sound in Washington State.
Vivienne I. Rebel, MD, PhD
Executive Vice President and Chief Science and Medical Officer
Dr. Rebel is a cancer (stem) cell biologist, with more than 20 years of experience in scientific research, focused on understanding the molecular events that lead to cancer development. She received her M.D. and Ph.D. from the Fre University in Amsterdam, The Netherlands, and post-doctoral training at the Dana-Farber Cancer Institute, Harvard Medical School. From 2005 to 2016, she led her own research group at The University of Texas (UT) Health Science Center at San Antonio, where she first collaborated with bioAffinity. Dr. Rebel received the 2012 Cancer Therapy and Research Center Discovery of the Year Award. She is the (co)author of more than 40 publications in peer-reviewed journals.
Michael Edwards, MBA, CPA
Chief Financial Officer
Mr. Edwards has more than 20 years of extensive experience in corporate ﬁnance and accounting. Most recently, he was the CFO for CytoBioscience and previously he was the CFO for OncoVista Innovative Therapies. He was an assistant controller at ILEX Oncology, and controller at Bionumerik Pharmaceuticals and U.S. Global Investors. Mr. Edwards started his career at PricewaterhouseCoopers. He is a Certiﬁed Public Accountant and holds a Bachelor’s degree in business administration from The University of Texas at San Antonio and a Master’s degree from The University of Texas.
William Bauta, PhD
Senior Vice President, Therapeutics
Dr. Bauta is a medicinal chemist with more than 25 years of experience in discovery, development, and commercialization of pharmaceuticals to treat oncology, virology, neuroscience, immunology, and metabolic diseases. He joined bioAffinity Technologies from Southwest Research Institute where he helped develop the Institute’s pharmaceuticals services and bioengineering business. Dr. Bauta was Associate Director of Science at Genzyme Corporation and held a similar position at Ilex Products, Inc., where he was responsible for the discovery, development, and FDA approval of multiple therapeutics. He holds several patents and has published in the journal Science and more than a dozen other scientific journals and conference proceedings. Dr. Bauta received his Ph.D. from the University of Chicago.
David Elzi, PhD
Vice President, Research
Dr. Elzi brings 20 years of research experience to bioAffinity where he leads research on the mechanism of porphyrin uptake in cancer cells that has resulted in therapeutic discoveries to selectively kill cancer without harm to normal tissue. Dr. Elzi earned his Ph.D. in Molecular and Cellular Biology from the University of Washington, in conjunction with the Fred Hutchinson Cancer Research Center. He subsequently performed post-doctoral research at the Bonfils Blood Center and University of Colorado Department of Surgery, where he studied the molecular mechanisms of transfusion-related lung injury. Dr. Elzi comes to bioAffinity from The UT Health Science Center where his research included applying proteomic techniques to study cellular senescence in primary and cancer cells. He has published more than 20 peer-reviewed articles.
Xavier T. Reveles, MS, CG(ASCP)GM
Vice President, Operations
Mr. Reveles brings more than 25 years of experience as a clinical geneticist skilled in the creation and management of CLIA clinical laboratories, coding and CPT reimbursement valuations. Mr. Reveles is board certified by the American Society of Clinical Pathology as a clinical specialist in cytogenetics. He was Laboratory Director for OncoPath Laboratory – START Cancer Center in San Antonio, Texas. Mr. Reveles is (co)author of 15 publications and three abstracts in peer-reviewed journals. He earned his Master’s Degree in biology/genetics from the University of The Incarnate Word in San Antonio, Texas.
Timothy P. Zannes, JD
Executive Vice President, General Counsel and Secretary
Mr. Zannes has been corporate legal counsel to both public and private biomedical firms for more than 16 years, having begun his legal career as a sole practitioner accepting criminal, business, family, and tort litigation. Prior to receiving his J.D., Mr. Zannes was a court bailiff and ran his own private investigation firm after serving as an investigator for the Albuquerque City Attorney. He received his J.D. from the University of New Mexico School of Law and attended the New England Conservatory with studies in violin and saxophone. Mr. Zannes began his undergraduate education at The University of North Carolina where he was a student athlete on scholarship. In addition to his duties as General Counsel and Secretary, Mr. Zannes is responsible for corporate compliance and directs Human Resources. Mr. Zannes and Maria Zannes are siblings.
Jennifer Rebeles, PhD
Vice President, Diagnostics
Dr. Rebeles brings 18 years of research experience to her work with bioAffinity where she directs the research and development of our porphyrin-based cancer diagnostics and has extensive experience in flow cytometry. She was Technical Director of the Flow Cytometry and Microarray Core at the Greehey Children’s Cancer Research Institute, and received her Masters degree in Biology at the University of Texas at San Antonio. She earned her Ph.D. in Nutritional Biochemistry from the University of North Carolina at Chapel Hill where she investigated the role of metabolism on immunity to infectious disease. Her previous position as a research scientist with the United States Air Force 59th Medical Wing included responsibility for identifying critical gaps in military medicine and scientific support for multiple research projects. Dr. Rebeles has published seven peer-reviewed papers, a book chapter, with several papers in preparation and holds multiple honors.
bioAffinity's Diagnostics Efforts
CyPath® uses a porphyrin molecule that displays an unusually high affinity to bind to cancer cells that fluoresce brightly when labeled to distinguish cancer from non-cancer cells using flow cytometry.
Our innovative scientific research is aimed at developing non-invasive diagnostics for various cancers and other lung diseases. Our first test, CyPath® Lung, is available through Precision Pathology Services to physicians for their patients at high risk for lung cancer.
This animated video produced by the Massachusetts Institute of Technology (MIT) Star CellBio introduces flow cytometry, a technique in which cells are suspended in a fluid and flow one at a time through a focus of exciting light, which is scattered in patterns characteristic to the cells and their components.
Cells are labeled with fluorescent markers so that light is first absorbed and then emitted at altered frequencies. A sensor detecting the emitted light measures the size and molecular characteristics of individual cells. Millions of cells can be examined in minutes and the resulting data is analyzed by computer. A picture of the lung environment is revealed by analyzing the cell populations in a sample to determine if a disease is present.
bioAffinity's Therapeutics Efforts
Through our subsidiary, OncoSelect® Therapeutics, our company focuses on advancing discoveries related to broad-spectrum cancer therapeutics. In researching porphyrins’ selectivity for cancer, we discovered novel therapies that kill cancer cells without harm to normal cells in vitro.
We will continue with animal studies to advance our discoveries. Our research also looks to attach cancer-killing cytotoxic drugs to porphyrins, a cancer-selective molecule that is taken up by tumors in much greater amounts than by non-cancer tissue.
Animation of a Porphyrin molecule